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This book covers the main mathematical and numerical models in computational electrocardiology, ranging from microscopic membrane models of cardiac ionic channels to macroscopic bidomain, monodomain, eikonal models and cardiac source representations. These advanced multiscale and nonlinear models describe the cardiac bioelectrical activity from the cell level to the body surface and are employed in both the direct and inverse problems of electrocardiology. The book also covers advanced numerical techniques needed to efficiently carry out large-scale cardiac simulations, including time and space discretizations, decoupling and operator splitting techniques, parallel finite element solvers. These techniques are employed in 3D cardiac simulations illustrating the excitation mechanisms, the anisotropic effects on excitation and repolarization wavefronts, the morphology of electrograms in normal and pathological tissue and some reentry phenomena. The overall aim of the book is to present rigorously the mathematical and numerical foundations of computational electrocardiology, illustrating the current research developments in this fast-growing field lying at the intersection of mathematical physiology, bioengineering and computational biomedicine. This book is addressed to graduate student and researchers in the field of applied mathematics, scientific computing, bioengineering, electrophysiology and cardiology.
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Had Mr. Tulloch, the headmaster and proprietor of a large school at Putney, been asked which was the most troublesome boy in his school, he would probably have replied, without hesitation, "Bob Repton." But, being a just and fair-minded man, he would have hastened to qualify this remark, by adding: "Most troublesome, but by no means the worst boy. You must understand that. He is always in scrapes, always in mischief. In all my experience I have never before come across a boy who had such an aptitude for getting into trouble; but I have nothing else to say against him. He is straightforward and manly. I have never known him to tell a lie, to screen himself. He is an example to many others in that way. I like the boy, in spite of the endless trouble he gives, and yet there is scarcely a day passes that I am not obliged to cane him; and even that does him no good, as far as I can see, for he seems to forget it, five minutes after it is over. I wonder, sometimes, if he has really got hardened, and doesn't feel it.
"On their way back to Rockdale," Dharma explained, "John stopped at a McDonalds drive-through. He got a few cheep burgers to share with me and we pulled around to the parking space to unbag and eat them. It was a special moment." There had been another moment that was not so great.
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